Configuring Files to launch with the Win E shortcut (without the need of AutoHotKey)

You can configure Files to launch using the Win + E shortcut (without AutoHotKey) as follows:

.vbs script

First create a VBScript script file that calls the File app:

WScript.CreateObject("Wscript.Shell").Run "C:\Windows\explorer.exe shell:AppsFolder\49306atecsolution.FilesUWP_et10x9a9vyk8t!App"

Save this script in a directory of your choice, e.g. "E:\Tools\Files\Files.vbs".

Registry

Now add the following to your registry entries to override the default Win + E shortcut (adapt the path of the .vbs script if necessary)*:

Windows Registry Editor Version 5.00
[HKEY_CURRENT_USER\SOFTWARE\Classes\CLSID\{52205fd8-5dfb-447d-801a-d0b52f2e83e1}]
[HKEY_CURRENT_USER\SOFTWARE\Classes\CLSID\{52205fd8-5dfb-447d-801a-d0b52f2e83e1}\shell]
[HKEY_CURRENT_USER\SOFTWARE\Classes\CLSID\{52205fd8-5dfb-447d-801a-d0b52f2e83e1}\shell\opennewwindow]
[HKEY_CURRENT_USER\SOFTWARE\Classes\CLSID\{52205fd8-5dfb-447d-801a-d0b52f2e83e1}\shell\opennewwindow\command]
@="wscript.exe \"E:\\Tools\\Files\\Files.vbs\"
"DelegateExecute"=""

No restart is required.

*There is no default registry entry, so you won't override anything (unless you already had another association)